Eveline Guého

Lomentospora prolificans is an emerging opportunistic fungal pathogen that causes a wide variety of infections in immunologically normal and immunosuppressed people and animals. It is resistant to most antifungal drugs and infections are often fatal. Drugs targeting the Class II dihydroorotate dehydrogenase (DHODH) proteins of L. prolificans, Scedosporium, Aspergillus and other deadly moulds are the basis for at least one new therapy, Olorofim, which is currently in phase 2b clinical trials and has received breakthrough status by FDA. For information on all DHODH proteins, please see

Malassezia sympodialis is a species in the genus Malassezia. It is characterized by a pronounced lipophily, unilateral, percurrent or sympodial budding and an irregular, corrugated cell wall ultrastructure. It is one of the most common species found on the skin of healthy and diseased individuals. It is considered to be part of the skin's normal human microbiota and begins to colonize the skin of humans shortly after birth. Malassezia sympodialis, often has a symbiotic or commensal relationship with its host, but it can act as a pathogen causing a number of different skin diseases, such as

Malassezia globosa is a species of yeast. The skin rash of tinea versicolor (pityriasis versicolor) is also due to infection by this fungus.

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